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1

Structure-functional analysis of interactions of terminal deoxynucleotidyl transferase with new non-nucleoside substrates

E. S. Matyugina, L. A. Alexandrova, M. V. Jasco, A. V. Ivanov, I. A. Vasiliev, V. L. Lapteva, A. L. Khandazhinskaya, M. K. Kukhanova

Journal:

Russian Journal of Bioorganic Chemistry

Année:

2009

Langue:

english

Fichier:

PDF, 312 KB

english, 2009

2

Design of Anti-HIV Compounds from Nucleoside to Nucleoside 5-Triphosphate Analogs. Problems and Perspectives

Kukhanova, Marina, Krayevsky, Alexander, Prusoff, William, Cheng, Yung-Chi

Journal:

Current Pharmaceutical Design

Année:

2000

Langue:

english

Fichier:

PDF, 100 KB

english, 2000

3

Synthesis and Antiherpetic Activity of Acyclovir Phosphonates.

Inna L. Karpenko, Maxim V. Jasko, Valeriya L. Andronova, Alexander V. Ivanov, Marina K. Kukhanova, George A. Galegov, Yury S. Skoblov

Journal:

Année:

2003

Fichier:

PDF, 106 KB

2003

4

New Lipophilic Derivatives of AZT and d4T 5′-Phosphonates

Elena A. Shirokova, Maxim V. Jasko, Anastasiya L. Khandazhinskaya, Dmitry V. Yanvarev, Yury S. Skoblov, Tatyana R. Pronayeva, Nina V. Fedyuk, Andrey G. Pokrovsky, Marina K. Kukhanova

Journal:

Année:

2004

Fichier:

PDF, 53 KB

2004

5

Phosphorodiamides as Prodrugs for Antiviral Nucleosides

Alexander V. Shipitsyn, Natalya F. Zakirova, Evgeny F. Belanov, Tatyana R. Pronyaeva, Nina V. Fedyuk, Marina K. Kukhanova, Andrey G. Pokrovsky

Journal:

Année:

2004

Fichier:

PDF, 52 KB

2004

6

A new chemical method of synthesis of modified nucleoside [32P]phosphates

D. V. Yanvarev, E. A. Shirokova, M. K. Kukhanova, Yu. S. Skoblov

Journal:

Journal of Labelled Compounds and Radiopharmaceuticals

Année:

2008

Langue:

english

Fichier:

PDF, 131 KB

english, 2008

7

1,2,4-Triazoloazine derivatives as a new type of herpes simplex virus inhibitors

S.L. Deev, M.V. Yasko, I.L. Karpenko, A.N. Korovina, A.L. Khandazhinskaya, V.L. Andronova, G.A. Galegov, T.S. Shestakova, E.N. Ulomskii, V.L. Rusinov, O.N. Chupakhin, M.K. Kukhanova

Journal:

Bioorganic Chemistry

Année:

2010

Langue:

english

Fichier:

PDF, 695 KB

english, 2010

8

Amino acid esters of 9-(2′,3′-dihydroxypropyl-1′)-adenine are the specific inhibitors of protein synthesis on ribosomes

B. P. Gottikh, A. A. Krayevsky, M. K. Kukhanova, A. A. Jatsyna, A. M. Kritzyn, C. L. Florentiev

Journal:

Molecular Biology Reports

Année:

1973

Langue:

english

Fichier:

PDF, 292 KB

english, 1973

9

Peptidyl-tRNA with a fluorescent label: Ribosome substrates in peptide bond formation

M. K. Kukhanova, A. A. Krayevsky, L. A. Alexandrova, S. A. Streltsov, B. P. Gottikh

Journal:

Molecular Biology Reports

Année:

1974

Langue:

english

Fichier:

PDF, 208 KB

english, 1974

10

Binding of oxytetracycline toE. coliribosomes

S. A. Streltsov, M. K. Kukhanova, A. A. Krayevsky, I. V. Beljavskaja, L. S. Victorova, G. V. Gursky, A. D. Treboganov, B. P. Gottikh

Journal:

Molecular Biology Reports

Année:

1974

Langue:

english

Fichier:

PDF, 313 KB

english, 1974

11

Catalysis of the peptide bond formation by 50 S subunits ofE. Coliribosomes with N-(formyl) methionine ester of adenylic acid as peptide donor

V. V. Kotusov, M. K. Kukhanova, A. A. Krayevsky, B. P. Gottikh

Journal:

Molecular Biology Reports

Année:

1976

Langue:

english

Fichier:

PDF, 275 KB

english, 1976

12

Structural—Functional Relationships between Terminal Deoxynucleotidyltransferase and 5′-Triphosphates of Nucleoside Analogs

M. K. Kukhanova, A. V. Ivanov, M. V. Jasko

Journal:

Biochemistry (Moscow)

Année:

2005

Langue:

english

Fichier:

PDF, 321 KB

english, 2005

13

Substrate properties of dinucleoside 5′,5″-oligophosphates in the reactions catalyzed by HIV reverse transcriptase,E. coliDNA polymerase I, andE. coliRNA polymerase

A. Yu. Skoblov, V. V. Sosunov, L. S. Victorova, Yu. S. Skoblov, M. K. Kukhanova

Journal:

Russian Journal of Bioorganic Chemistry

Année:

2005

Langue:

english

Fichier:

PDF, 196 KB

english, 2005

14

Enzymatic Synthesis of Bis(5′-Nucleosidyl) Tetra- and Triphosphates

A. Yu. Skoblov, M. V. Yas'ko, A. M. Murabuldaev, M. K. Kukhanova, Yu. S. Skoblov

Journal:

Russian Journal of Bioorganic Chemistry

Année:

2005

Langue:

english

Fichier:

PDF, 67 KB

english, 2005

15

New Nonnucleoside Substrates for Terminal Deoxynucleotidyl Transferase: Synthesis and Dependence of Substrate Properties on Structure

A. L. Khandazhinskaya, M. K. Kukhanova, M. V. Jasko

Journal:

Russian Journal of Bioorganic Chemistry

Année:

2005

Langue:

english

Fichier:

PDF, 81 KB

english, 2005

16

Cell Metabolism of Acyclovir Phosphonate Derivatives and Antiherpesvirus Activity of their Combinations with α2-Interferon

Yuri S. Skoblov, Inna L. Karpenko, Maxim V. Jasko, Marina K. Kukhanova, Valery L. Andronova, Georgy A. Galegov, Georgy V. Sidorov, Nicolai F. Myasoedov

Journal:

Chemical Biology & Drug Design

Année:

2007

Langue:

english

Fichier:

PDF, 534 KB

english, 2007

17

Antiherpetic Properties of Acyclovir 5′-Hydrogenphosphonate and the Mutation Analysis of Herpes Virus Resistant Strains

Anna A. Gus’kova, Mikhail Yu. Skoblov, Anna N. Korovina, Maxim V. Yasko, Inna L. Karpenko, Marina K. Kukhanova, Valeria L. Andronova, George A. Galegov, Yuri S. Skoblov

Journal:

Chemical Biology & Drug Design

Année:

2009

Langue:

english

Fichier:

PDF, 268 KB

english, 2009

18

5′-Phosphonate Derivatives of 2′,3′-Dideoxy-3′-Thiacytidine as New Anti-HIV Prodrugs

Anastasia L. Khandazhinskaya, Maxim V. Jasko, Inna L. Karpenko, Pavel N. Solyev, Natalia A. Golubeva, Marina K. Kukhanova

Journal:

Chemical Biology & Drug Design

Année:

2011

Langue:

english

Fichier:

PDF, 227 KB

english, 2011

19

Hepatitis C virus helicase/NTPase: an efficient expression system and new inhibitors

A. V. Mukovnya, V. L. Tunitskaya, A. L. Khandazhinskaya, N. A. Golubeva, N. F. Zakirova, A. V. Ivanov, M. K. Kukhanova, S. N. Kochetkov

Journal:

Biochemistry (Moscow)

Année:

2008

Langue:

english

Fichier:

PDF, 290 KB

english, 2008

20

Mutations in the DNA polymerase and thymidine kinase genes of herpes simplex virus clinical isolates resistant to antiherpetic drugs

A. N. Korovina, A. A. Gus’kova, M. Yu. Skoblov, V. L. Andronova, G. A. Galegov, S. N. Kochetkov, M. K. Kukhanova, Yu. S. Skoblov

Journal:

Molecular Biology

Année:

2010

Langue:

english

Fichier:

PDF, 189 KB

english, 2010

21

Novel herpes simplex virus and human immunodeficiency virus inhibitors based on phosphonate nucleoside analogs

A. N. Korovina, M. V. Yasco, A. V. Ivanov, A. L. Khandazhinskaya, E. V. Karamov, G. V. Kornilaeva, M. K. Kukhanova

Journal:

Moscow University Chemistry Bulletin

Année:

2008

Langue:

english

Fichier:

PDF, 165 KB

english, 2008

22

Synthesis and Substrate Properties of Modified Nucleoside 5"-Triphosphates Mimicking dATP in the Reactions of DNA Synthesis Catalyzed by DNA Polymerases

Yu. A. Sharkin, D. G. Semizarov, L. S. Viktorova, M. K. Kukhanova

Journal:

Russian Journal of Bioorganic Chemistry

Année:

2001

Langue:

english

Fichier:

PDF, 113 KB

english, 2001

23

The Effect of Pyrophosphate Analogues on the Activity of the Inorganic Pyrophosphatase fromEscherichia coli

N. F. Zakirova, A. V. Ivanov, Yu. S. Skoblov, M. K. Kukhanova

Journal:

Russian Journal of Bioorganic Chemistry

Année:

2002

Langue:

english

Fichier:

PDF, 54 KB

english, 2002

24

New Phosphonoformic Acid Derivatives of 3′-Azido-3′-Deoxythymidine

E. A. Shirokova, M. V. Jasko, A. L. Khandazhinskaya, A. V. Ivanov, D. V. Yanvarev, Yu. S. Skoblov, T. R. Pronyaeva, N. V. Fedyuk, A. G. Pokrovskii, M. K. Kukhanova

Journal:

Russian Journal of Bioorganic Chemistry

Année:

2004

Langue:

english

Fichier:

PDF, 109 KB

english, 2004

25

The Synthesis and Antiherpetic Activity of Acyclovir Phosphonate Esters

M. V. Jasko, N. Yu. Ulanova, V. L. Andronova, A. V. Ivanov, I. L. Karpenko, M. K. Kukhanova, G. A. Galegov, Yu. S. Skoblov

Journal:

Russian Journal of Bioorganic Chemistry

Année:

2004

Langue:

english

Fichier:

PDF, 100 KB

english, 2004

26

Influence of rubomycin, carminomycin, doxorubicin, and their semisynthetic derivatives on DNA synthesis in vitro

Sh. Kh. Minasyan, T. A. Rozovskaya, M. K. Kukhanova, L. S. Povarov, E. N. Olsuf'eva, M. N. Preobrazhenskaya

Journal:

Pharmaceutical Chemistry Journal

Année:

1989

Langue:

english

Fichier:

PDF, 312 KB

english, 1989

27

Cellular metabolism of modified nucleosides that suppress production of human immunodeficiency virus. III. (Review)

M. K. Kukhanova, A. A. Kraevskii

Journal:

Pharmaceutical Chemistry Journal

Année:

1992

Langue:

english

Fichier:

PDF, 574 KB

english, 1992

28

Synthesis, structure and certain biochemical properties of 31-branched thymidines and their 51-phosphate derivatives

I. I. Fedorov, E. M. Kaz'mina, N. A. Novikov, G. V. Gurskaya, A. V. Bochkarev, M. V. Yas'ko, L. S. Viktorova, M. K. Kukhanova, A. A. Kraevskii, Ya. Bal'zarini, E. Clerk

Journal:

Pharmaceutical Chemistry Journal

Année:

1992

Langue:

english

Fichier:

PDF, 1.36 MB

english, 1992

29

Approaches to the search for drugs against AIDS

A. A. Kraevskii, R. Sh. Bibilashvili, M. K. Kukhanova, Yu. E. Raifel'd

Journal:

Pharmaceutical Chemistry Journal

Année:

1988

Langue:

english

Fichier:

PDF, 1.08 MB

english, 1988

30

Aminoacyl derivatives of nucleosides, nucleotides, and polynucleotides

L. A. Aleksandrova, T. M. Kutuzova, A. A. Kraevskii, M. K. Kukhanova, B. P. Gottikh

Journal:

Russian Chemical Bulletin

Année:

1977

Langue:

english

Fichier:

PDF, 628 KB

english, 1977

31

Polyribosome patterns in EMC-virus infected Krebs-2 cells and cell extracts

N. V. Kaverin, M. K. Kukhanova

Journal:

Cellular and Molecular Life Sciences

Année:

1967

Langue:

english

Fichier:

PDF, 236 KB

english, 1967

32

2′,-dideoxycytidine 5′-triphosphate analogs as substrate for human DNA polymerases: implication for the mechanism of toxicity

M. Kukhanova, S.H. Liu, C.K. Chu, Y.-C. Cheng

Journal:

Antiviral Research

Année:

1995

Langue:

english

Fichier:

PDF, 83 KB

english, 1995

33

Intracellular metabolism and pharmacokinetics of 5′-hydrogenphosphonate of 3′-azido-2′,3′-dideoxythymidine, a prodrug of 3′-azido-2′,3′-dideoxythymidine

Yurii Skoblov, Inna Karpenko, Elena Shirokova, Konstantin Popov, Valerya Andronova, Georgii Galegov, Marina Kukhanova

Journal:

Antiviral Research

Année:

2004

Langue:

english

Fichier:

PDF, 155 KB

english, 2004

34

Hepatitis C Virus NS5A Protein In Vitro Modulates Template Selection by the RNA-dependent RNA Polymerase

Olga Ivanova, Vera Tunitskaya, Alexander Ivanov, Vladimir Mitkevich, Vladimir Prassolov, Alexander Makarov, Marina Kukhanova, Sergey Kochetkov

Journal:

Antiviral Research

Année:

2009

Langue:

english

Fichier:

PDF, 146 KB

english, 2009

35

New Nucleoside and bis-Nucleoside-Phosphonate Conjugates: Design, Stability, and Anti-HIV Evaluation

Marina Kukhanova, Maxim Jasko, Dmitry Yanvarev, Inna Karpenko, Alexander Shipitzyn, Anastasia Khandazhinskaya

Journal:

Antiviral Research

Année:

2010

Langue:

english

Fichier:

PDF, 82 KB

english, 2010

36

Hepatitis C virus NS5A protein modulates template selection by the RNA polymerase in in vitro system

Alexander V. Ivanov, Vera L. Tunitskaya, Olga N. Ivanova, Vladimir A. Mitkevich, Vladimir S. Prassolov, Alexander A. Makarov, Marina K. Kukhanova, Sergey N. Kochetkov

Journal:

Année:

2009

Langue:

english

Fichier:

PDF, 364 KB

english, 2009

37

Inhibition of Epstein-Barr virus replication by a novel l-nucleoside, 2′-fluoro-5-methyl-β-l-arabinofuranosyluracil

Gang-Qing Yao, Shwu-Huey Liu, Edgar Chou, Marina Kukhanova, Chung K. Chu, Yung-Chi Cheng

Journal:

Biochemical Pharmacology

Année:

1996

Langue:

english

Fichier:

PDF, 752 KB

english, 1996

38

On the mechanism of peptide bond synthesis in the ribosome. 3′-O-phenylalanyl-2′-O-methyladenosine as a peptide acceptor

V.A. Pozdnyakov, Yu.V. Mitin, M.K. Kukhanova, L.V. Nikolaeva, A.A. Krayevsky, B.P. Gottikh

Journal:

Année:

1972

Langue:

english

Fichier:

PDF, 245 KB

english, 1972

39

The study of the stimulating mechanism of the peptidyl donor activity of 2′(3′)-O-(N-formylmethionyl)-adenosine-5′-phosphate in peptidyl transferase of E. coli ribosome

A.A. Krayevsky, L.S. Victorova, V.V. Kotusov, M.K. Kukhanova, A.D. Treboganov, N.B. Tarussova, B.P. Gottikh

Journal:

Année:

1976

Langue:

english

Fichier:

PDF, 199 KB

english, 1976

40

Synthesis of thioamide bond catalyzed by E. coli ribosomes

L.S. Victorova, V.V. Kotusov, A.V. Azhaev, A.A. Krayevsky, M.K. Kukhanova, B.P. Gottikh

Journal:

Année:

1976

Langue:

english

Fichier:

PDF, 254 KB

english, 1976

41

Kinetic constants for model substrates of peptidyltransferase donor site of Escherichia coli ribosomes

S. Streltsov, A. Kosenjuk, M. Kukhanova, A. Krayevsky, B. Gottikh

Journal:

Année:

1979

Langue:

english

Fichier:

PDF, 400 KB

english, 1979

42

The donor site of the peptidyltransferase center of ribosomes: Equilibrium association constants of model substrates and inhibitors

M. Kukhanova, S. Streltsov, L. Victorova, A. Azhayev, B. Gottikh, A. Krayevsky

Journal:

Année:

1979

Langue:

english

Fichier:

PDF, 468 KB

english, 1979

43

Ribosomes of rat liver catalyze ‘minimal’ donor reaction

M.K. Kukhanova, A.A. Krayevsky, B.P. Gottikh, J. Stahl

Journal:

Année:

1979

Langue:

english

Fichier:

PDF, 282 KB

english, 1979

44

Peptidyl transferase center of Escherichia coli ribosomes: Interrelations between the substrates

Marina K. Kukhanova, Ljubov S. Victorova, Saul B. Bourd, Boris P. Gottikh, Alexander A. Krayevsky, Mathias Sprinzl

Journal:

Année:

1980

Langue:

english

Fichier:

PDF, 358 KB

english, 1980

45

Synthesis of an unnatural P-N bond catalyzed with Escherichia coli ribosomes

N.B. Tarussova, G.M. Jacovleva, L.S. Victorova, M.K. Kukhanova, R.M. Khomutov

Journal:

Année:

1981

Langue:

english

Fichier:

PDF, 232 KB

english, 1981

46

On substrate specificity of the donor site of the Escherichia coli ribosomal peptidyl transferase center: Synthesis of dipeptides from 3′-terminal fragments of aminoacyl-tRNA

S. Bourd, L. Victorova, M. Kukhanova

Journal:

Année:

1982

Langue:

english

Fichier:

PDF, 243 KB

english, 1982

47

Peptidyltransferase center of ribosomes: On the mechanism of action of alkaloid lycorine

Marina Kukhanova, Ljubov Victorova, Alexander Krayevsky

Journal:

Année:

1983

Langue:

english

Fichier:

PDF, 446 KB

english, 1983

48

Properties of 2′,3′-dideoxy-2′,3′-dehydrothymidine 5′-triphosphate in terminating DNA synthesis catalyzed by several different DNA polymerases

Natalia Dyatkina, Shahnara Minassian, Marina Kukhanova, Alexander Krayevsky, Martin von Janta-Lipinsky, Zurab Chidgeavadze, Robert Beabealashvilli

Journal:

Année:

1987

Langue:

english

Fichier:

PDF, 475 KB

english, 1987

49

Inhibition of reverse transcription in rat liver intracisternal A-particles by thymidine derivatives

Galina B. Pyrinova, Elena A. Kuzminova, Rudolf I. Salganik, Alexander A. Krayevsky, Marina M. Kukhanova

Journal:

Année:

1989

Langue:

english

Fichier:

PDF, 334 KB

english, 1989

50

Pyrophosphate analogues in pyrophosphorolysis reaction catalyzed by DNA polymerases

Tatyana Rozovskaya, Natalya Tarussova, Shahnara Minassian, Alexey Atrazhev, Marina Kukhanova, Alexander Krayevsky, Zurab Chidgeavadze, Robert Beabealashvilli

Journal:

Année:

1989

Langue:

english

Fichier:

PDF, 415 KB

english, 1989